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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEarly potential impairment of renal sensory nerves in streptozotocin-induced diabetic rats: role of neurokinin receptorspt_BR
dc.contributor.authorBoer, PApt_BR
dc.contributor.authorRossi, CDpt_BR
dc.contributor.authorMesquita, FFpt_BR
dc.contributor.authorGontijo, JARpt_BR
unicamp.authorBoer, Patricia Aline Rossi, Cintia de Lima Mesquita, Flavia Fernandes Gontijo, Jose A. R. Univ Estadual Campinas, Fac Ciencias Med, Nucleo Med & Cirurgia Expt, Disciplina Med Interna,Lab Metab Hidro Salino, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectafferent renal nerve activitypt_BR
dc.subjectdiabetes mellituspt_BR
dc.subjectneurokinin receptorspt_BR
dc.subject.wosGene-related Peptidept_BR
dc.subject.wosDorsal-root Gangliapt_BR
dc.subject.wosAldose Reductase Inhibitionpt_BR
dc.subject.wosRenin-angiotensin Systempt_BR
dc.subject.wosAcute Volume Expansionpt_BR
dc.subject.wosNeurofilament Phosphorylationpt_BR
dc.description.abstractBackground. Electrophysiological studies in the mammalian kidney have identified two major classes of sensory receptors of the afferent renal nerves; chemoreceptors (CR) and mechanoreceptors (MR). The localization of calcitonin gene-related peptide (CGRP) and substance P (SP) in these renal pelvic sensory neurons provides an anatomical basis for a possible functional interaction between the two neuropeptides and SP receptor. The present study was performed to examine the possible changes in the responsiveness of renal sensory SP and CGRP receptors in rats with streptozotocin (STZ)-induced diabetes mellitus. Due to the crucial role of renal pelvic SP and CGRP receptors in the activation of renal sensory neurons by various stimuli, we examined whether the responsiveness of MR or CR activation and the dorsal root ganglia content of neuropeptides and neurokinin 1 receptors (NK(1)R) were altered in diabetic rats compared with non-diabetic rats. Methods. Afferent renal nerve activity (ARNA) was recorded from the peripheral portion of the cut end of one renal nerve branch placed on a bipolar silver wire electrode. T(13) dorsal root ganglia (DRG) immunoreactivity was performed to NK(1)R, SP and CGRP. Results. The results of the current study confirmed that the stimulation of renal MR and CR elicited a renorenal reflex response, and that the renal pelvic administration of SP and CGRP increased ipsilateral ARNA and contralateral urinary sodium excretion with no changes in arterial pressure. We also found a decrease in NK(1)R expression followed by an increase in SP and CGRP levels in the DRG of diabetic rats. The ARNA response, produced by renal pelvic MR and CR stimulation, was found to be significantly attenuated in the STZ-induced diabetic model. Conclusions. These data may indicate a compensatory synthesis and/or abnormal axonal delivery of neurokinins from the cell body to synaptic portions of the neuron as the underlying reason for attenuated ARNA in renal sensory neurons of diabetic
dc.relation.ispartofNephrology Dialysis Transplantationpt_BR
dc.relation.ispartofabbreviationNephrol. Dial. Transplant.pt_BR
dc.publisherOxford Univ Presspt_BR
dc.identifier.citationNephrology Dialysis Transplantation. Oxford Univ Press, v. 26, n. 3, n. 823, n. 832, 2011.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberCNPq [500868/91-3]pt
dc.description.sponsordocumentnumberFAPESP [06/52431-1]pt
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