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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDrug Release from Microspheres and Nanospheres of Poly(lactide-co-glycolide) without Sphere Separation from the Release Mediumpt_BR
dc.contributor.authorda Silva, ARpt_BR
dc.contributor.authorZaniquelli, MEDpt_BR
dc.contributor.authorBaratti, MOpt_BR
dc.contributor.authorJorge, RApt_BR
unicamp.authorJorge, Renato Atilio Univ Estadual Campinas, Inst Chem, Dept Phys Chem, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorBaratti, Mariana O. Univ Estadual Campinas, Fac Med Sci, Dept Clin Med, BR-13083887 Campinas, SP, Brazilpt_BR
unicamp.authorZaniquelli, M. Elisabete D. Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Chem, BR-14040901 Ribeirao Preto, SP, Brazilpt_BR
unicamp.authorda Silva, Andre R. Fed Inst Espirito Santo, BR-29192733 Aracruz, ES, Brazilpt_BR
dc.subjectdrug releasept_BR
dc.subject.wosLoaded Biodegradable Nanospherespt_BR
dc.subject.wosPhotodynamic Therapypt_BR
dc.subject.wosPhotosensitizing Efficacypt_BR
dc.subject.wosSolvent Evaporationpt_BR
dc.subject.wosPlga Nanoparticlespt_BR
dc.subject.wosCentral Metalpt_BR
dc.description.abstractA new technique using diffuse reflectance spectroscopy was developed that enables the monitoring of encapsulated drug release without particle separation from the assayed medium. Studies of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III) (InTPP) release from microspheres and nanospheres of poly(lactide-co-glycolide) (PLGA) were performed using this new technique. The release of InTPP was biphasic, with an initial fast release followed by a second slower release. Mathematical models applied to the release profiles showed that the release of InTPP from the nanospheres was controlled by diffusion, which is to be expected for a substance homogeneously dispersed within the spheres. However, due to the large size distribution of the microspheres loaded with InTPP, the release profiles were irregular, hampering an adequate fit to mathematical models. Confocal analysis of microparticles showed that the InTPP appeared to be homogenously distributed within the microspheres and no preferential distribution of InTPP towards the interior or towards the surface of the spheres was
dc.relation.ispartofJournal Of The Brazilian Chemical Societypt_BR
dc.relation.ispartofabbreviationJ. Braz. Chem. Soc.pt_BR
dc.publisher.citySao Paulopt_BR
dc.publisherSoc Brasileira Quimicapt_BR
dc.identifier.citationJournal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 21, n. 2, n. 214, n. 225, 2010.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipUniversidade Estadual de Campinaspt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
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