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|Type:||Artigo de periódico|
|Title:||DRUG KINETICS AND DRUG-RESISTANCE IN OPTIMAL CHEMOTHERAPY|
|Abstract:||A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth this strategy proved to be suboptimal under certain conditions.|
|Editor:||Elsevier Science Publ Co Inc|
|Citation:||Mathematical Biosciences. Elsevier Science Publ Co Inc, v. 125, n. 2, n. 191, n. 209, 1995.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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