Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63503
Type: Artigo de periódico
Title: DRUG KINETICS AND DRUG-RESISTANCE IN OPTIMAL CHEMOTHERAPY
Author: COSTA, MIS
BOLDRINI, JL
BASSANEZI, RC
Abstract: A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth this strategy proved to be suboptimal under certain conditions.
Editor: Elsevier Science Publ Co Inc
Rights: fechado
Identifier DOI: 10.1016/0025-5564(94)00027-W
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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