Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||DRUG KINETICS AND DRUG-RESISTANCE IN OPTIMAL CHEMOTHERAPY|
|Abstract:||A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth this strategy proved to be suboptimal under certain conditions.|
|Editor:||Elsevier Science Publ Co Inc|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.