Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/635
Type: Artigo de periódico
Title: The Incapacity of the Surgeon to Identify NASH in Bariatric Surgery Makes Biopsy Mandatory
Author: TEIXEIRA, Antonio Roberto Franchi
BELLODI-PRIVATO, Marta
CARVALHEIRA, Jose Barreto
PILLA, Victor Fernando
PAREJA, Jose Carlos
D`ALBUQUERQUE, Luiz Augusto Carneiro
Abstract: Nonalcoholic steatohepatitis (NASH) is a morbid condition highly related to obesity. It is unclear if the macroscopic liver appearance correlates with the histopathologic findings. The goal of this prospective study was to determine the relationship between the intraoperative liver appearance and the histopathologic diagnosis of NASH in morbidly obese subjects undergoing bariatric surgery. We also aimed to determine variables that could predict NASH preoperatively. Consecutive 51 subjects undergoing bariatric surgery without evidence of other liver disease underwent intraoperative liver biopsy. An intraoperative liver visual (macroscopic and tactile examination) was recorded. The liver aspect was compared with the liver histologic findings. Histological assessment was categorized into two groups: NASH and non-NASH (including normal histology and simple steatosis). Clinical and biochemical parameters were obtained from the patient databases and were compared between groups to identify preoperatively predictive factors of NASH. From 51 patients, only one presented totally normal histology. Forty-three (86.2%) presented simple steatosis, and seven (13.7%) were classified as NASH. Clinical parameters were not different between groups. At biochemical analysis, only VLDL cholesterol level was significantly higher in the NASH group (p = 0.037) but yet within the normal range. Association between macroscopic liver appearance and the presence of histological NASH is poor (sensitivity of 14%, specificity of 56%, positive predictive value of 5%, and negative predictive value of 80%). No predictor of NASH was found. Surgeons` evaluation could not identify NASH individuals. Routine liver biopsy during bariatric operations is mandatory to differentiate NASH and nonalcoholic fatty liver disease.
Subject: Liver biopsy
Obesity
Steatosis
Bariatric surgery
Nonalcoholic Steatohepatitis (NASH)
Predictors of NASH
Country: Estados Unidos
Editor: SPRINGER
Rights: fechado
Identifier DOI: 10.1007/s11695-009-9980-x
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000272665600012&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.1007/s11695-009-9980-x
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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