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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDoxycycline ameliorates the dystrophic phenotype of skeletal and cardiac muscles in mdx micept_BR
dc.contributor.authorPereira, JApt_BR
dc.contributor.authorTaniguti, APTpt_BR
dc.contributor.authorMatsumura, Cpt_BR
dc.contributor.authorMarques, MJpt_BR
dc.contributor.authorNeto, HSpt_BR
unicamp.author.emailnsanto@unicamp.brpt_BR
unicamp.authorPereira, Juliano Alves Tiemi Taniguti, Ana Paula Matsumura, Cintia Marques, Maria Julia Neto, Humberto Santo Univ Estadual Campinas, Inst Biol, Dept Anat Biol Celular Fisiol & Biofis, UNICAMP, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectcardiac musclept_BR
dc.subjectDMDpt_BR
dc.subjectdoxycyclinept_BR
dc.subjectdystrophypt_BR
dc.subjectmdxpt_BR
dc.subjectskeletal musclept_BR
dc.subject.wosDuchenne Muscular-dystrophypt_BR
dc.subject.wosDeficient Musclept_BR
dc.subject.wosCardiomyopathypt_BR
dc.subject.wosMousept_BR
dc.subject.wosProgressionpt_BR
dc.subject.wosPathologypt_BR
dc.subject.wosNecrosispt_BR
dc.subject.wosDegenerationpt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosStrategiespt_BR
dc.description.abstractIntroduction: We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Methods: Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Results: Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. Conclusions: This study provides evidence that doxycycline may be a potential therapeutic agent for DMD. Muscle Nerve 46: 400406, 2012pt
dc.relation.ispartofMuscle & Nervept_BR
dc.relation.ispartofabbreviationMuscle Nervept_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationSEPpt_BR
dc.identifier.citationMuscle & Nerve. Wiley-blackwell, v. 46, n. 3, n. 400, n. 406, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume46pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage400pt_BR
dc.description.lastpage406pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0148-639Xpt_BR
dc.identifier.wosidWOS:000308084500012pt_BR
dc.identifier.doi10.1002/mus.23331pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsordocumentnumberFAPESP [04/15526-9, 08/58491-1]pt
dc.description.sponsordocumentnumberCNPq [301306/2010-9, 302006/2009-5]pt
dc.description.sponsordocumentnumberCNPq [140557/07-5]pt
dc.description.sponsordocumentnumberFAPESP [08/54775-5]pt
dc.date.available2014-07-30T17:04:50Z
dc.date.available2015-11-26T16:46:24Z-
dc.date.accessioned2014-07-30T17:04:50Z
dc.date.accessioned2015-11-26T16:46:24Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63482
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63482-
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