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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNear-fatal pulmonary embolism in an experimental model: hemodynamic, gasometric and capnographic variablespt_BR
dc.contributor.authorPereira, DJpt_BR
dc.contributor.authorMoreira, MMpt_BR
dc.contributor.authorPaschoal, IApt_BR
dc.contributor.authorMartins, LCpt_BR
dc.contributor.authorMetze, Kpt_BR
dc.contributor.authorMoreno, Hpt_BR
unicamp.authorPereira, Daniel Jose Moreira, Marcos Mello Paschoal, Ilma Aparecida Martins, Luiz Claudio Metze, Konradin Moreno Junior, Heitor Univ Estadual Campinas, Campinas, SP, Brazilpt_BR
dc.subjectPulmonary embolismpt_BR
dc.subjectHypertension, pulmonarypt_BR
dc.subjectModels, animalpt_BR
dc.subject.wosGas-exchange Alterationspt_BR
dc.description.abstractIntroduction: Experimental studies on pulmonary embolism (PE) are usually performed under mechanical ventilation. Most patients with suspicion of PE enter the Emergency Services in spontaneous breathing and environmental air. Thus, under these conditions, measurements. of hemodynamic, gasometric and capnographic variables contribute largely to a more specific comprehension of cardiopulmonary and gasometric alterations in the acute phase of the disease. Studies which evaluated animals under conditions are lacking. Objective: This study aimed to submit animals under spontaneous ventilation and without supplemental oxygen to PE. Methods: PE was induced in six pigs using autologous blood clots, and cardiorespiratory and gasometric records were performed before and after PE. The values of "near fatal" mean pulmonary arterial pressure (MPAP) were previously determined. Results: The presence of obstructive shock could be evidenced by increased MPAP (from 17.8 +/- 3.5 to 41.7 +/--3.3 mmHg) (P<0.0001) and decreased cardiac output (from 4.9 +/- 1.0 to 2.7 +/- 1.0 L/min) (P<0.003). Consequently, metabolic acidosis occurred (Lac art) (from 2.4 +/--0.6 to 5.7 +/- 1.8 mmol/L) (P<0.0001). It was observed hypoxemia (from 73.5 +/- 12.7 to 40.3 +/- 4.6 mmHg) (P<0.0001); however, PaCO(2) did not vary (from 44.9 +/- 4.4 to 48.2 +/- 6.0 mmHg) (NS). There were significant increases in both P(a-et)CO(2) (from 4.8 +/- 2.8 to 37.2 +/- 5.8 mmHg) and P(A-a)O(2) (from 8.2 +/- 8.9 to 37.2 +/- 10.3 mmHg) (both P<0.0001). There was also a significant increase in the total alveolar minute volume (from 4.0 +/- 0.9 to 10.6 +/- 2.9 L/min) (P<0.0001). Conclusion: In this model, the near fatal MPAP was from 2 to 2.5 times the basal MPAP; and the capnographic variables, associated with arterial and venous gasometry, showed effective in discriminating an acute obstructive
dc.relation.ispartofRevista Brasileira De Cirurgia Cardiovascularpt_BR
dc.relation.ispartofabbreviationRev. Bras. Cir. Cardiovasc.pt_BR
dc.publisher.citySao Paulo Sppt_BR
dc.publisherSoc Brasil Cirurgia Cardiovascpt_BR
dc.identifier.citationRevista Brasileira De Cirurgia Cardiovascular. Soc Brasil Cirurgia Cardiovasc, v. 26, n. 3, n. 462, n. 468, 2011.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipResearch in the State of Sao Paulo [02/05252-3]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberResearch in the State of Sao Paulo [02/05252-3]pt
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