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Type: Artigo de periódico
Title: Natural polymer-based magnetic hydrogels: Potential vectors for remote-controlled drug release
Author: Paulino, AT
Pereira, AGB
Fajardo, AR
Erickson, K
Kipper, MJ
Muniz, EC
Belfiore, LA
Tambourgi, EB
Abstract: The preparation and characterization of natural polymer-based hydrogels that contain 50-nm diameter magnetite (i.e., FeO:Fe2O3) nanoparticles are described herein. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the efficiency of the polysaccharide-modifying process. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and compressive moduli demostrate that the presence of magnetite improves thermal and mechanical resistance. Transient diffusion of water in magnetic hydrogels was analyzed via boundary layer mass transfer across an expaning interface, and the degree of swelling of these polysaccharide hydrogels decreases in the presence of magnetite, with no variation in the binary diffusion mechanism. The absence of hysteresis loops and coercivity observed via magnetometry suggests that magnetic hydrogels are useful for remote-controlled drug release, as demonstrated by magnetic-field-induced release of curcumin. Experiments reveal that magnetic hydrogels with greater magnetic susceptibility have the potential to release larger concentrations of drugs from the hydrogel network. (c) 2012 Elsevier Ltd. All rights reserved.
Subject: Polysaccharide
Magnetic hydrogel
Controlled release
Country: Inglaterra
Editor: Elsevier Sci Ltd
Citation: Carbohydrate Polymers. Elsevier Sci Ltd, v. 90, n. 3, n. 1216, n. 1225, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.carbpol.2012.06.051
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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