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Type: Artigo de periódico
Title: Natural and Prosthetic Heart Valve Calcification: Morphology and Chemical Composition Characterization
Author: Weska, RF
Aimoli, CG
Nogueira, GM
Leirner, AA
Maizato, MJS
Higa, OZ
Polakievicz, B
Pitombo, RNM
Beppu, MM
Abstract: Calcification is the most common cause of damage and subsequent failure of heart valves. Although it is a common phenomenon, little is known about it, and less about the inorganic phase obtained from this type of calcification. This article describes the scanning electron microscopy (SEM)/energy dispersive X-ray spectroscopy and Ca K-edge X-ray absorption near edge structure (XANES) characterization performed in natural and bioprosthetic heart valves calcified in vivo (in comparison to in vitro-calcified valves). SEM micrographs indicated the presence of deposits of similar morphology, and XANES results indicate, at a molecular level, that the calcification mechanism of both types of valves are probably similar, resulting in formation of poorly crystalline hydroxyapatite deposits, with Ca/P ratios that increase with time, depending on the maturation state. These findings may contribute to the search for long-term efficient anticalcification treatments.
Subject: Calcification
Cardiac valves
X-ray absorption near edge structure
Country: EUA
Editor: Wiley-blackwell
Citation: Artificial Organs. Wiley-blackwell, v. 34, n. 4, n. 311, n. 318, 2010.
Rights: fechado
Identifier DOI: 10.1111/j.1525-1594.2009.00858.x
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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