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Type: Artigo de periódico
Title: NAD(P)H- and superoxide-dependent nitric oxide degradation by rat liver mitochondria
Author: Oliveira, HC
Saviani, EE
Salgado, I
Abstract: Mitochondria consume nitric oxide (NO) mainly through reaction with superoxide anion (O(2)(-)). Here, we analyzed the O(2)(-) sources for NO degradation by isolated rat liver mitochondria. Electron leakage from complex III and reverse electron transport to complex I accounted for O(2)(-) -dependent NO degradation by mitochondria in the presence of a protonmotive force. Mitochondria incubated with NAD(P) H also presented intense O(2)(-) generation and NO degradation rates that were insensitive to respiratory inhibitors and abolished after proteinase treatment. These results suggest that an outer membrane-localized NAD(P) H oxidase activity, in addition to the electron leakage from the respiratory chain, promotes O(2)(-) -dependent NO degradation in rat liver mitochondria. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Subject: NAD(P)H oxidase
Nitric oxide
Rat liver mitochondria
Superoxide anion
Country: Holanda
Editor: Elsevier Science Bv
Citation: Febs Letters. Elsevier Science Bv, v. 583, n. 13, n. 2276, n. 2280, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2009.06.012
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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