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|Type:||Artigo de periódico|
|Title:||NAD(P)H- and superoxide-dependent nitric oxide degradation by rat liver mitochondria|
|Abstract:||Mitochondria consume nitric oxide (NO) mainly through reaction with superoxide anion (O(2)(-)). Here, we analyzed the O(2)(-) sources for NO degradation by isolated rat liver mitochondria. Electron leakage from complex III and reverse electron transport to complex I accounted for O(2)(-) -dependent NO degradation by mitochondria in the presence of a protonmotive force. Mitochondria incubated with NAD(P) H also presented intense O(2)(-) generation and NO degradation rates that were insensitive to respiratory inhibitors and abolished after proteinase treatment. These results suggest that an outer membrane-localized NAD(P) H oxidase activity, in addition to the electron leakage from the respiratory chain, promotes O(2)(-) -dependent NO degradation in rat liver mitochondria. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.|
Rat liver mitochondria
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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