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Type: Artigo de periódico
Title: Burkitt's lymphoma of the jaws in the Amazon region of Brazil
Author: Rebelo-Pontes, HA
de Abreu, MC
Guimaraes, DM
Fonseca, FP
de Andrade, BAB
de Almeida, OP
Junior, DDP
Correa-Pontes, FS
Abstract: Objectives: To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. Study Design: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV). Results: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis. Conclusions: Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity.
Subject: Burkitt's lymphoma
Amazon region
Country: Espanha
Editor: Medicina Oral S L
Rights: aberto
Identifier DOI: 10.4317/medoral.18936
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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