Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Cardiovascular Responses to Bothrops alternatus (Urutu) Snake Venom in Anesthetized Dogs
Author: Dias, L
Rodrigues, MAP
Smaal, A
Renno, AL
Mello, SM
Moreno, H
Hyslop, S
Abstract: The cardiovascular responses to Bothrops alternatus snake venom in anesthetized dogs were investigated. Venom (0.3 mg/kg, i.v.) markedly decreased arterial blood pressure, coronary perfusion pressure, and cardiac output (CO) after 5 min, with progressive recovery of the first two parameters to pre-venom levels after 3 h; CO showed little recovery. There was an abrupt, sustained decrease in left and right ventricular systolic work and stroke volume but no significant changes in heart rate, electrocardiogram, and pulmonary hemodynamics; systemic vascular resistance increased from 1 h onwards. A venom dose of 1 mg/kg produced more pronounced cardiovascular alterations, with a progressive decrease to death. There were no significant changes in blood gas (pO(2), pCO(2), HCO3, SBC, and SBE) and metabolic (pH, lactate, glucose, creatine kinase activity, Na+, and K+) parameters, although there was a transitory increase in plasma lactate dehydrogenase 2 min after the lower venom dose. There were no cardiac histological alterations, but microaneurysms and epithelial desquamation were seen in renal tubules. Circulating venom concentrations (determined by ELISA) decreased rapidly after administration, but venom was still detectable after 4 h. These results show that in dogs, B. alternatus venom produces marked hypotension and a direct cardiac action, with few metabolic alterations.
Subject: Blood pressure
Bothrops alternatus
Metabolic alterations
Snake venom
Country: EUA
Editor: Humana Press Inc
Citation: Cardiovascular Toxicology. Humana Press Inc, v. 12, n. 3, n. 243, n. 257, 2012.
Rights: fechado
Identifier DOI: 10.1007/s12012-012-9163-1
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000306739100006.pdf963.47 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.