Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63123
Type: Artigo de periódico
Title: Cannabis Sativa Smoke Inhalation Decreases Bone Filling Around Titanium Implants: A Histomorphometric Study in Rats
Author: Nogueira, GD
Cadide, T
Rosa, BT
Neiva, TG
Tunes, R
Peruzzo, D
Nociti, FH
Cesar, JB
Abstract: Purpose: Although the harmful effect of tobacco smoking on titanium implants has been documented, no studies have investigated the effects of cannabis sativa (marijuana) smoking. Thus, this study investigated whether marijuana smoke influences bone healing around titanium implants. Materials: Thirty Wistar rats were used. After anesthesia, the tibiae surface was exposed and I screw-shaped titanium implant was placed bilaterally. The animals were randomly assigned to one of the following groups: control (n = 15) and marijuana smoke inhalation (MSI) 8 min/d (n = 15). Urine samples were obtained to detect the presence of tetrahidro-cannabinoid. After 60 days, the animals were killed. The degree of bone-to-implant contact and the bone area within the limits of the threads of the implant were measured in the cortical (zone A) and cancellous bone (zone B). Results: Tetra-hidro-cannabinoid in urine was positive only for the rates of MSI group. Intergroup analysis did differences in zone not indicate differences in zone A-cortical bone (P > 0.01), however, a negative effect of marijuana smoke (MSI group) was observed ill zone B-cancellous bone for bone-to-implant contact and bone area (Student's t test, P < 0.01) values. Conclusions: Considering the limitations of the present study, the deleterious impact of cannabis sativa smoke oil bone healing may represent a new concern for implant success/failure. (Implant Dent 2008;17:461-470)
Subject: cannabis sativa
titanium implants
rat model
bone
Country: EUA
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/ID.0b013e31818c5a2a
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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