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Type: Artigo de periódico
Title: Candida dubliniensis in a Brazilian family with an HIV 1-infected child: Identification, antifungal susceptibility, drug accumulation and sterol composition
Author: de Melo, NR
Taguchi, H
Culhari, VVP
Sano, A
Fukushima, K
Miyaji, M
Manning, N
Kelly, SL
Vilela, MMS
Abstract: This study investigated the prevalence of C. dubliniensis in a Brazilian family with an HIV-infected child. A total of 42 oral isolates were obtained from eight family members. The identification of C. dubliniensis was performed by polymerase chain reactions (PCR) using primers against a specific sequence of the C. dubliniensis cytochrome b gene. Only the HIV-infected child and his grandmother were colonized by C. dubliniensis. In this study C. dubliniensis isolated from the HIV-infected child exhibited high susceptibility for azoles tested with MICs of 0.125 and 0.5 mu g/mL for voriconazole and fluconazole, respectively. Accumulation of [H-3] fluconazole in C. dubliniensis isolated from the HIV-infected child was slightly reduced in comparison to the reference susceptible strain. C. dubliniensis isolates had significantly lower ergosterol levels in comparison to C. albicans reference strains.
Subject: Candida dubliniensis
antifungal agents
sterol composition
Country: Brasil
Editor: Soc Brasileira Microbiologia
Rights: aberto
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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