Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63102
Type: Artigo de periódico
Title: Chiral allylsilane additions to chiral N-Boc-alpha-amino aldehydes
Author: Dias, LC
Meira, PRR
Abstract: Addition of chiral allylsilane 4 to chiral N-Boc-alpha-amino aldehydes in the presence of SnCl4 in CH2Cl2 at -78 degrees C affords 1,2-syn homoallylic alcohols, potential intermediates for the synthesis of hydroxyethylene peptide isosteres. The diastereoselectivity depends on the aldehyde absolute configuration, with (R)-alpha-aminoaldehydes (matched case/anti-Felkin addition) exhibiting higher stereoselectivity than its enantiomer (mismatched case/Felkin addition).
Subject: chiral allylsilane
alpha-amino aldehydes
dipeptide isosteres
homoallylic alcohols
oxazolidines
Country: Alemanha
Editor: Georg Thieme Verlag
Rights: embargo
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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