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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.subject.otherDRUG-RESISTANCEen
dc.subject.otherAIDS PATIENTSen
dc.subject.otherSAO-PAULOen
dc.subject.otherADULTSen
dc.subject.otherAFRICAen
dc.subject.otherIMPACTen
dc.typeArtigo de periódicopt_BR
dc.type.categoryoriginal articlept_BR
dc.type.versionpublishedVersionpt_BR
dc.titleTuberculous meningitis in HIV-infected patients in Brazil: clinical and laboratory characteristics and factors associated with mortalitypt_BR
dc.contributor.authorCRODA, Mariana G.pt_BR
dc.contributor.authorVIDAL, Jose E.pt_BR
dc.contributor.authorHERNANDEZ, Adrian V.pt_BR
dc.contributor.authorMOLIN, Tiago Dalpt_BR
dc.contributor.authorGUALBERTO, Felipe A.pt_BR
dc.contributor.authorOLIVEIRA, Augusto C. Penalva dept_BR
unicamp.authorOLIVEIRA, Augusto C. Penalva de:Universidade Estadual de Campinas, Hospital de Clínicas, Serviço de Neurologiapt_BR
unicamp.author.externalCRODA, Mariana G.pt
unicamp.author.externalHERNANDEZ, Adrian V.pt
unicamp.author.externalMOLIN, Tiago Dalpt
unicamp.author.externalGUALBERTO, Felipe A.pt
unicamp.author.externalVIDAL, Jose E.pt
dc.subjectTuberculous meningitispt_BR
dc.subjectDiagnosispt_BR
dc.subjectCentral nervous systempt_BR
dc.subjectTuberculosispt_BR
dc.subjectAcquired immunodeficiency syndromept_BR
dc.subjectBrazilpt_BR
dc.subject.wosInfectious Diseasespt_BR
dc.description.abstractBackground: Tuberculous meningitis (TBM) is a growing problem in HIV-infected patients in developing countries, where there is scarce data about this co-infection. Our objectives were to analyze the main features and outcomes of HIV-infected patients with TBM. Methods: This was a retrospective study of HIV-infected Brazilian patients admitted consecutively for TBM. All patients had Mycobacterium tuberculosis isolated from the cerebrospinal fluid (CSF). Presenting clinical and laboratory features were studied. Multivariate analysis was used to identify variables associated with death during hospitalization and at 9 months after diagnosis. Survival was estimated using the Kaplan-Meier method. Results: We included 108 cases (median age 36 years, 72% male). Only 15% had fever, headache, and meningeal signs simultaneously. Forty-eight percent had extrameningeal tuberculosis. The median CD4+ cell count was 65 cells/mu l. Among 90 cases, 7% had primary resistance to isoniazid and 9% presented multidrug-resistant strains. The overall mortality during hospitalization was 29% and at 9 months was 41%. Tachycardia and prior highly active antiretroviral therapy (HAART) were associated with 9-month mortality. The 9-month survival rate was 22% (95% confidence interval 12-43%). Conclusions: Clinical and laboratory manifestations were unspecific. Disseminated tuberculosis and severe immunosuppression were common. Mortality was high and the 9-month survival rate was low. Tachycardia and prior HAART were associated with death within 9 months of diagnosis. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en
dc.relation.ispartofInternational Journal of Infectious Diseasespt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherELSEVIER SCI LTDpt_BR
dc.date.issued2010pt_BR
dc.identifier.citationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.14, n.7, p.E586-E591, 2010pt_BR
dc.language.isoengpt_BR
dc.description.volume14pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpageE586pt_BR
dc.description.lastpageE591pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright ELSEVIER SCI LTDpt_BR
dc.sourceWOSpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1201-9712pt_BR
dc.identifier.doi10.1016/j.ijid.2009.08.012pt_BR
dc.identifier.urlhttp://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000278650400007&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecordpt_BR
dc.identifier.urlhttp://dx.doi.org/10.1016/j.ijid.2009.08.012pt_BR
dc.date.available2013-07-26T17:58:11Z
dc.date.available2016-06-30T13:52:05Z-
dc.date.accessioned2013-07-26T17:58:11Z
dc.date.accessioned2016-06-30T13:52:05Z-
dc.description.provenanceMade available in DSpace on 2013-07-26T17:58:11Z (GMT). No. of bitstreams: 2 art_CRODA_Tuberculous_meningitis_in_HIV-infected_patients_in_Brazil_2010.pdf.txt: 35731 bytes, checksum: 9221b88ed9c0c7e41a65e4306b665716 (MD5) art_CRODA_Tuberculous_meningitis_in_HIV-infected_patients_in_Brazil_2010.pdf: 161295 bytes, checksum: a947ebca8b9bec5466aa264c20946a69 (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2016-06-30T13:52:05Z (GMT). No. of bitstreams: 2 art_CRODA_Tuberculous_meningitis_in_HIV-infected_patients_in_Brazil_2010.pdf.txt: 35731 bytes, checksum: 9221b88ed9c0c7e41a65e4306b665716 (MD5) art_CRODA_Tuberculous_meningitis_in_HIV-infected_patients_in_Brazil_2010.pdf: 161295 bytes, checksum: a947ebca8b9bec5466aa264c20946a69 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/630
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/630-
dc.contributor.departmentNeurologia
dc.contributor.unidadeHCpt
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