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Type: Artigo de periódico
Title: Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes
Author: Alvares, LE
Winterbottom, FL
Sobreira, DR
Xavier, J
Schubert, FR
Dietrich, S
Abstract: Dapper (Dpr) proteins are context-dependent regulators of Wnt and Tgf beta signaling. However, although inroads into their molecular properties have been made, their expression and biological function are not understood. Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only. The genes are expressed in distinct patterns at gastrulation, neurulation, and organogenesis stages of development with key expression domains being the posterior primitive streak, anterior node and notochord, presomitic mesoderm (segmental plate), lateral and cardiac mesoderm, limb mesenchyme, and neurogenic placodes for Dpr1, and anterior primitive streak, node, epithelial somites, embryonic muscle stem cells, oral ectoderm and endoderm, neural crest cells, limb ectoderm, and lung buds for Dpr2. Expression overlaps in a few tissues; however, in several tissues, expression is complementary. Developmental Dynamics 238:1166-1178, 2009. (C) 2009 Wiley-Liss, Inc.
Subject: Dapper
primitive streak
head process
prechordal plate
segmental plate
embryonic muscle stem cells
lateral mesoderm
cardiac mesoderm
neural crest cells
neurogenic placodes
foregut endoderm
oral ectoderm
lung bud
Country: EUA
Editor: Wiley-liss
Rights: fechado
Identifier DOI: 10.1002/dvdy.21950
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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