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Type: Artigo de periódico
Title: Chernoenzymatic syntheses of (R)-2-bromo-, (R)-2-chloro- and (R)-2-azido-1-(1,3-benzodioxol-5-yl)-1-ethanol
Author: Antunes, H
Fardelone, LC
Rodrigues, JAR
Moran, PJS
Abstract: Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N-3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57-99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(-)-epinephrine, (R)-(-)-norepinephrine and (R)-(-)-isoproterenol. (C) 2004 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.tetasy.2004.07.029
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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