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Type: Artigo de periódico
Title: Chemopreventive potential of the tannase-mediated biotransformation of green tea
Author: Macedo, JA
Ferreira, LR
Camara, LE
Santos, JC
Gambero, A
Macedo, GA
Ribeiro, ML
Abstract: Green tea (Camellia sinensis) is one of the most widely consumed beverages in the world. The cancer chemopreventive qualities of green tea have been well documented. Epigallocatechin gallate (EGCG) is often described as the most potently chemopreventive green tea catechin; however, the low bioavailability of EGCG is a limiting factor for its biological effect. Thus, the aim of this work was to test the chemopreventive potential of green tea extract and EGCG after tannase-mediated hydrolysis. The results showed that the biotransformed compounds retained most of the beneficial properties of the original compounds, and some beneficial properties were improved in the biotransformed compounds. Biotransformation of EGCG decreased its toxicity without affecting its antiproliferative effects. Furthermore, human cells gene expression profiling showed that the biotransformed compounds modulated the expression of several genes related to carcinogenesis. These results demonstrate the benefits of the biotechnological modification of natural food molecules, allowing the improvement of the nutraceutical potential of a beverage as green tea. (C) 2012 Elsevier Ltd. All rights reserved.
Subject: Chemoprevention
Comet assay
Gene expression
Green tea
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.foodchem.2012.01.041
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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