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Type: Artigo de periódico
Title: Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine
Author: Sucena, SF
Paiva, REF
Abbehausen, C
Mattos, IB
Lancellotti, M
Formiga, ALB
Corbi, PP
Abstract: A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. H-1, C-13 and N-15 nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of the ligand to Au(I) through the N atom of the ethanamine group. Theoretical (DFT) calculations confirmed the IR assignments and permit proposing an optimized geometry for the complex. The gold(I)-rimantadine complex (Au-RTD) is soluble in methanol, ethanol, dimethylsulfoxide, acetone and acetonitrile. The preliminary kinetic studies based on UV-vis spectroscopic measurements indicate the stability of the compound in solution. Antibacterial activities of the complex were evaluated by an antibiogram assay. The Au-RTD complex showed an effective in vitro antibacterial activity against the Pseudomonas aeruginosa, Escherichia coli (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains. (C) 2011 Elsevier BM. All rights reserved.
Subject: Gold(I)
NMR spectroscopy
DFT studies
Antibacterial assay
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.saa.2011.12.043
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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