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Type: Artigo de periódico
Title: Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities
Author: Costa, EV
Dutra, LM
Salvador, MJ
Ribeiro, LHG
Gadelha, FR
de Carvalho, JE
Abstract: The essential oils from the leaves of Annona pickelii and Annona salzmannii (Annonaceae) were obtained by hydrodistillation using a Clevenger apparatus, and analysed by GC-MS and GC-FID. A total of 21 compounds were identified in the essential oil of A. pickelii and 23 in that of A. salzmannii; sesquiterpenes predominated in both essential oils. Bicyclogermacrene (38.0%), (E)-caryophyllene (27.8%), -copaene (6.9%) and -humulene (4.0%) were the main components of A. pickelii, while -cadinene (22.6%), (E)-caryophyllene (21.4%), -copaene (13.3%), bicyclogermacrene (11.3%) and germacrene D (6.9%) were the main components of A. salzmannii. The biological activities of the essential oils against Trypanosoma cruzi epimastigote forms and cytotoxicity against tumour cell lines (antitumour) were investigated. The essential oils showed potent trypanocidal and antitumour activities with values of IC50 lower than 100 mu gmL(-1).
Subject: Annona pickelii
Annona salzmannii
essential oil
antitumour and trypanocidal activities
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Natural Product Research. Taylor & Francis Ltd, v. 27, n. 11, n. 997, n. 1001, 2013.
Rights: fechado
Identifier DOI: 10.1080/14786419.2012.686913
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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