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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleChemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophyllapt_BR
dc.contributor.authorSalvador, MJpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
dc.contributor.authorWisniewski, Apt_BR
dc.contributor.authorKassuya, CALpt_BR
dc.contributor.authorSantos, EPpt_BR
dc.contributor.authorRiva, Dpt_BR
dc.contributor.authorStefanello, MEApt_BR
unicamp.author.emailmarcosjs@unicamp.brpt_BR
unicamp.authorSalvador, Marcos Jose Univ Estadual Campinas, Curso Farm, Dept Biol Vegetal, Inst Biol, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorde Carvalho, Joao Ernesto Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorWisniewski-, Alberto, Jr. Univ Fed Sergipe, Dept Quim, Sergipe, Brazilpt_BR
unicamp.authorKassuya, Candida A. L. Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Mato Grosso, Brazilpt_BR
unicamp.authorSantos, Elide P. Univ Fed Parana, Dept Bot, BR-80060000 Curitiba, Parana, Brazilpt_BR
unicamp.authorRiva, Dilamara Alves Stefanello, Maria Elida Univ Fed Parana, Dept Quim, BR-80060000 Curitiba, Parana, Brazilpt_BR
dc.subjectCasearia lasiophyllapt_BR
dc.subjectSalicaceaept_BR
dc.subjectessential oilpt_BR
dc.subjectgermacrene Dpt_BR
dc.subjectbeta-caryophyllenept_BR
dc.subjectantitumorpt_BR
dc.subject.wosSylvestrispt_BR
dc.subject.wosAntiulcerpt_BR
dc.description.abstractThe essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), beta-caryophyllene (14.7%), delta-cadinene (6.2%), and alpha-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 mu g/mL), with exception of NCI-H460 cell line (TGI 191.31. mu g/mL). The highest activity was observed against UACC-62 (TGI 7.30 mu g/mL), and K562 (TGI 7.56 mu g/mL) cell lines. The observed activity could be related to high content of germacrene D and. beta-caryophyllene, compounds known as cytotoxic.pt
dc.relation.ispartofRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosypt_BR
dc.relation.ispartofabbreviationRev. Bras. Farmacogn.-Braz. J. Pharmacogn.pt_BR
dc.publisher.cityJoao Pessoapt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSoc Brasileira Farmacognosiapt_BR
dc.date.issued2011pt_BR
dc.date.monthofcirculationSEP-OCTpt_BR
dc.identifier.citationRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 21, n. 5, n. 864, n. 868, 2011.pt_BR
dc.language.isoenpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage864pt_BR
dc.description.lastpage868pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0102-695Xpt_BR
dc.identifier.wosidWOS:000296085200013pt_BR
dc.identifier.doi10.1590/S0102-695X2011005000073pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipFAEPEX-UNICAMPpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T16:52:16Z
dc.date.available2015-11-26T16:40:47Z-
dc.date.accessioned2014-07-30T16:52:16Z
dc.date.accessioned2015-11-26T16:40:47Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62993
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62993-
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