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Type: Artigo de periódico
Title: Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla
Author: Salvador, MJ
de Carvalho, JE
Wisniewski, A
Kassuya, CAL
Santos, EP
Riva, D
Stefanello, MEA
Abstract: The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), beta-caryophyllene (14.7%), delta-cadinene (6.2%), and alpha-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 mu g/mL), with exception of NCI-H460 cell line (TGI 191.31. mu g/mL). The highest activity was observed against UACC-62 (TGI 7.30 mu g/mL), and K562 (TGI 7.56 mu g/mL) cell lines. The observed activity could be related to high content of germacrene D and. beta-caryophyllene, compounds known as cytotoxic.
Subject: Casearia lasiophylla
essential oil
germacrene D
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Citation: Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 21, n. 5, n. 864, n. 868, 2011.
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2011005000073
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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