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Type: Artigo de periódico
Title: Chemical Composition and Cytotoxic Activity of Essential Oil from Myrcia laruotteana Fruits
Author: Stefanello, MEA
Riva, D
Simionatto, EL
de Carvalho, JE
Ruiz, ALTG
Salvador, MJ
Abstract: The essential oil isolated by hydrodistillation from unripe fruits of Myrcia laruotteana Camb. (Myrtaceae) was analyzed by GC and CG/MS. Forty-four components were identified, representing around 83% of total oil. The major components were a-bisabolol (23.6%) and a-bisabolol oxide B (11.5%). The cytotoxicity of the oil and of a fraction rich in a-bisabolol was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), 786.0 (kidney), NCI-H460 (lung), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The oil exhibited antiproliferative activity against all cell lines (TGI < 100 mu g/mL), with exception of NCI-H460 cell line (TGI > 125 mu g/mL). The highest activity of the oil was observed against U251 (TGI 20.46 mu g/mL), 786.0 (TGI 20.74 mu g/mL), UACC-62 (TGI 26.98 mu g/mL) and PC-3 (TGI 27.63 mu g/mL) cell lines. The fraction rich in alpha-bisabol showed a similar activity profile. It was most active against OVCAR-3 (TGI 8.58 mu g/mL) and 786.0 (TGI 8.74 mu g/mL).
Subject: Myrcia laruotteana
essential oil composition
alpha-bisabolol oxide B
antiproliferative activity
Country: EUA
Editor: Taylor & Francis Inc
Citation: Journal Of Essential Oil Research. Taylor & Francis Inc, v. 23, n. 5, n. 7, n. 10, 2011.
Rights: fechado
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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