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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleChemical composition and biological activity of a new type of Brazilian propolis: Red propolispt_BR
dc.contributor.authorAlencar, SMpt_BR
dc.contributor.authorOldoni, TLCpt_BR
dc.contributor.authorCastro, MLpt_BR
dc.contributor.authorCabral, ISRpt_BR
dc.contributor.authorCosta-Neto, CMpt_BR
dc.contributor.authorCury, JApt_BR
dc.contributor.authorRosalen, PLpt_BR
dc.contributor.authorIkegaki, Mpt_BR
unicamp.author.emailalencar@esalq.usp.brpt_BR
unicamp.authorUniv Sao Paulo, Luiz Queiroz Coll Agr, Dept Agri Food Ind Food & Nutr, BR-13418900 Piracicaba, SP, Brazil Univ Estadual Campinas, Fac Dent Piracicaba, Dept Physiol Sci, Campinas, SP, Brazil Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-05508 Sao Paulo, Brazil Univ Fed Alfenas, Alfenas, MG, Brazilpt_BR
dc.subjectpropolispt_BR
dc.subjectantibacterial activitypt_BR
dc.subjectantioxidant activitypt_BR
dc.subjectcytotoxic activitypt_BR
dc.subjectchemical analysispt_BR
dc.subjectisoflavonespt_BR
dc.subject.wosApis-mellifera Propolispt_BR
dc.subject.wosAntioxidant Activitypt_BR
dc.subject.wosMutans Streptococcipt_BR
dc.subject.wosBotanical Originpt_BR
dc.subject.wosCuban Propolispt_BR
dc.subject.wosPlatymiscium-floribundumpt_BR
dc.subject.wosCaries Developmentpt_BR
dc.subject.wosConstituentspt_BR
dc.subject.wosGrowthpt_BR
dc.subject.wosGlucosyltransferasespt_BR
dc.description.abstractPropolis has been used as a medicinal agent to treat infections and promote wound healing for centuries. The aim of the present study was to test the antimicrobial, antioxidant, and cytotoxic activities of a new type of Brazilian propolis, popularly called red propolis, as well as to analyze its chemical composition. The antimicrobial activity against Staphylococcus aureus ATCC 25923 and Staphylococcus mutans UA159 was evaluated and the chloroform fraction (Chlo-fr) was the most active with lower MIC ranging from 25 to 50 mu g/ml. The hexane fraction (H-fr), having the highest concentration of total flavonoids, showed the best sequestrating activity for the free radical DPPH. The ethanolic extract of propolis (EEP) showed cytotoxic activity for the HeLa tumor cells with an IC50 of 7.45 mu g/ml. When the EEP was analyzed by GC-MS, seven new compounds were found, among which four were isoflavones. Our results showed that the red propolis has biologically active compounds that had never been reported in other types of Brazilian propolis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.pt
dc.relation.ispartofJournal Of Ethnopharmacologypt_BR
dc.relation.ispartofabbreviationJ. Ethnopharmacol.pt_BR
dc.publisher.cityClarept_BR
dc.publisher.countryIrlandapt_BR
dc.publisherElsevier Ireland Ltdpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationSEP 5pt_BR
dc.identifier.citationJournal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 113, n. 2, n. 278, n. 283, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume113pt_BR
dc.description.issuenumber2pt_BR
dc.description.initialpage278pt_BR
dc.description.lastpage283pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0378-8741pt_BR
dc.identifier.wosidWOS:000249456900013pt_BR
dc.identifier.doi10.1016/j.jep.2007.06.005pt_BR
dc.date.available2014-11-18T13:25:14Z
dc.date.available2015-11-26T17:29:14Z-
dc.date.accessioned2014-11-18T13:25:14Z
dc.date.accessioned2015-11-26T17:29:14Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T13:25:14Z (GMT). No. of bitstreams: 1 WOS000249456900013.pdf: 200383 bytes, checksum: c067cfd4e8c28c2956147a7e13ab6b9a (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:29:14Z (GMT). No. of bitstreams: 2 WOS000249456900013.pdf: 200383 bytes, checksum: c067cfd4e8c28c2956147a7e13ab6b9a (MD5) WOS000249456900013.pdf.txt: 33856 bytes, checksum: 02ec71405731c436955cf47583172aed (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62987pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/62987
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62987-
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