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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCHEMICAL AND PHOTOCHEMICAL GENERATED CARBON-CENTERED RADICAL INTERMEDIATE AND ITS REACTION WITH DEOXYRIBONUCLEIC-ACIDpt_BR
dc.contributor.authorJUSTO, GZpt_BR
dc.contributor.authorLIVOTTO, PRpt_BR
dc.contributor.authorDURAN, Npt_BR
unicamp.authorUNIV ESTADUAL CAMPINAS,INST QUIM,BIOL CHEM LAB,BR-13081920 CAMPINAS,BRAZILpt_BR
dc.subjectDNApt_BR
dc.subjectALKYLATIONpt_BR
dc.subjectFREE RADICALSpt_BR
dc.subjectHYDRAZINEpt_BR
dc.subjectTHEORETICAL CALCULATIONSpt_BR
dc.subjectCARBON-CENTERED RADICALpt_BR
dc.subject2-PHENYLETHYL HYDRAZINEpt_BR
dc.subject.wosChain Oxidation Pathwayspt_BR
dc.subject.wosElectron-spin-resonancept_BR
dc.subject.wosFluorescence Enhancementpt_BR
dc.subject.wosHydrazine Derivativespt_BR
dc.subject.wosNucleic-acidspt_BR
dc.subject.wosPurine-basespt_BR
dc.subject.wosDnapt_BR
dc.subject.wosMetabolismpt_BR
dc.subject.wosNucleosidespt_BR
dc.subject.wosComplexespt_BR
dc.description.abstractThe possible action of carbon-centered radicals in promoting damage to DNA is explored by generation of the 2-phenylethyl radical. The radical is generated during oxidation of phenelzine (2-phenylethyl hydrazine) by ferricyanide, as well as optically from phenylpropionic acid. Covalent binding of the 2-phenylethyl radical to DNA is suggested by studies with the plasmid pBR 322 DNA. Other sensitive techniques used to study DNA damage were the interaction with formaldehyde at 60 degrees C and the fluorescence of DNA-Tb(III) and DNA-DAPI complexes. Theoretical MNDO calculations indicated a preferential attack at position 8 of the guanine residues. This study shows that the 2-phenylethyl radical is able to induce primary effects on nucleic acid structure, leading to alkylated products, especially at purine rings.pt
dc.relation.ispartofFree Radical Biology And Medicinept_BR
dc.relation.ispartofabbreviationFree Radic. Biol. Med.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued1995pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationFree Radical Biology And Medicine. Pergamon-elsevier Science Ltd, v. 19, n. 4, n. 431, n. 440, 1995.pt_BR
dc.language.isoenpt_BR
dc.description.volume19pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage431pt_BR
dc.description.lastpage440pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0891-5849pt_BR
dc.identifier.wosidWOS:A1995RN64800004pt_BR
dc.identifier.doi10.1016/0891-5849(95)00036-Wpt_BR
dc.date.available2014-12-16T11:36:36Z
dc.date.available2015-11-26T17:25:51Z-
dc.date.accessioned2014-12-16T11:36:36Z
dc.date.accessioned2015-11-26T17:25:51Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:36:36Z (GMT). No. of bitstreams: 1 WOSA1995RN64800004.pdf: 912476 bytes, checksum: 8d64baf64d3c32187b06dff0eff9e2a3 (MD5) Previous issue date: 1995en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:25:51Z (GMT). No. of bitstreams: 2 WOSA1995RN64800004.pdf: 912476 bytes, checksum: 8d64baf64d3c32187b06dff0eff9e2a3 (MD5) WOSA1995RN64800004.pdf.txt: 44187 bytes, checksum: 97f6e71bd73359f5f7f0740e065e0255 (MD5) Previous issue date: 1995en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62966pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/62966
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62966-
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