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Type: Artigo de periódico
Title: Characterization of the inclusion complex ropivacaine: beta-cyclodextrin
Author: Fraceto, LF
Goncalves, MM
Moraes, CM
de Araujo, DR
Zanella, L
de Paula, E
Pertinhez, TDA
Abstract: Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
Subject: ropivacame
Country: Brasil
Editor: Soc Brasileira Quimica
Citation: Quimica Nova. Soc Brasileira Quimica, v. 30, n. 5, n. 1203, n. 1207, 2007.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000500028
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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