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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCharacterization of Poly (L-co-D,L Lactic Acid) and a Study of Polymer-tissue Interaction in Subcutaneous Implants in Wistar Ratspt_BR
dc.contributor.authorCiambelli, GSpt_BR
dc.contributor.authorPerez, MOpt_BR
dc.contributor.authorSiqueira, GVpt_BR
dc.contributor.authorCandella, MApt_BR
dc.contributor.authorMotta, ACpt_BR
dc.contributor.authorDuarte, MATpt_BR
dc.contributor.authorAlberto-Rincon, MDpt_BR
dc.contributor.authorDuek, EADpt_BR
unicamp.author.emaileliduek@fem.unicamp.brpt_BR
unicamp.authorCiambelli, Giuliano Serafino Perez, Mariana Ortega Siqueira, Guilherme Vasconcelos Candella, Marco Aurelio Motta, Adriana Cristina Duarte, Marcia Adriana Tomaz Pontifical Catholic Univ Sao Paulo PUC SP, Fac Med Sci, BR-18030095 Sorocaba, SP, Brazilpt_BR
unicamp.authorAlberto-Rincon, Maria do Carmo Pontifical Catholic Univ Sao Paulo PUC SP, Fac Med Sci, Dept Physiol Sci, BR-18030095 Sorocaba, SP, Brazilpt_BR
unicamp.authorde Rezende Duek, Eliana Aparecida Univ Estadual Campinas, Dept Mat Engn, Fac Mech Engn, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectPLDLApt_BR
dc.subjectdegradation in vitropt_BR
dc.subjecttissuept_BR
dc.subject.wosIn-vivopt_BR
dc.subject.wosDegradationpt_BR
dc.subject.wosMorphologypt_BR
dc.subject.wosCopolymerpt_BR
dc.subject.wosMembranespt_BR
dc.subject.wosVitropt_BR
dc.description.abstractPoly (L-co-D,L lactic acid) (PLDLA) is an important biomaterial because of its biocompatibility properties that promote cellular regeneration and growth. The aim of this study was to evaluate the polymer-tissue interaction of PLDLA implants in the dorsal subcutaneous tissue of male Wistar rats at various intervals (2, 7, 15, 30, 60 and 90 days) after implantation. Physical properties such as the glass transition point (Tg), degradation behavior and other mechanical properties were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), scanning electron microscopy (SEM) and tension tests. Analysis of the degradation of PLDLA membranes in vitro showed that the polymer became crystalline as a function of the degradation time. Mechanical tension tests showed that the polymer behaved like a ductile material: when subjected to constant tension it initially suffered deformation, then elongation and finally ruptured. TGA/MEV provided evidence of PLDLA membrane degradation. For histological analysis, samples from each group were processed in xylol/paraffin, except for the 60 - and 90 - day samples. Each of the latter samples was divided in two: one half was treated with xylol/paraffin and the other with historesin. Light microscopy showed the adhesion of cells to the biomaterial, the formation of a conjunctive capsule around the implant, the presence of epithelioid cells, the formation of foreign body giant cells and angiogenesis. During degradation, the polymer showed a 'lace' - like appearance when processed in xylol/paraffin compared to the formation of "centripetal cracks in the form of glove fingers" when embedded in historesin.pt
dc.relation.ispartofMaterials Research-ibero-american Journal Of Materialspt_BR
dc.relation.ispartofabbreviationMater. Res.-Ibero-am. J. Mater.pt_BR
dc.publisher.citySao Carlospt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherUniv Fed Sao Carlos, Dept Engenharia Materialspt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationJAN-FEBpt_BR
dc.identifier.citationMaterials Research-ibero-american Journal Of Materials. Univ Fed Sao Carlos, Dept Engenharia Materials, v. 16, n. 1, n. 28, n. 37, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume16pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage28pt_BR
dc.description.lastpage37pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1516-1439pt_BR
dc.identifier.wosidWOS:000314791100004pt_BR
dc.identifier.doi10.1590/S1516-14392012005000146pt_BR
dc.description.sponsorshipPIBIC/CEPE (Programa Institucional de Bolsas de Iniciacao Cientifica - Conselho de Ensino Pesquisa e Extensao)pt_BR
dc.date.available2014-07-30T16:51:58Z
dc.date.available2015-11-26T16:29:12Z-
dc.date.accessioned2014-07-30T16:51:58Z
dc.date.accessioned2015-11-26T16:29:12Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T16:51:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:29:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62877
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62877-
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