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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCharacteristics of resistant hypertension: ageing, body mass index, hyperaldosteronism, cardiac hypertrophy and vascular stiffnesspt_BR
dc.contributor.authorMartins, LCpt_BR
dc.contributor.authorFigueiredo, VNpt_BR
dc.contributor.authorQuinaglia, Tpt_BR
dc.contributor.authorBoer-Martins, Lpt_BR
dc.contributor.authorYugar-Toledo, JCpt_BR
dc.contributor.authorMartin, JFVpt_BR
dc.contributor.authorDemacq, Cpt_BR
dc.contributor.authorPimenta, Ept_BR
dc.contributor.authorCalhoun, DApt_BR
dc.contributor.authorMoreno, Hpt_BR
unicamp.authorMartins, L. C. Figueiredo, V. N. Quinaglia, T. Boer-Martins, L. Demacq, C. Moreno, H., Jr. Univ Estadual Campinas, Cardiovasc Pharmacol Lab, Fac Med Sci, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorMartins, L. C. Figueiredo, V. N. Quinaglia, T. Boer-Martins, L. Demacq, C. Moreno, H., Jr. Univ Estadual Campinas, Clin Hosp, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorYugar-Toledo, J. C. Martin, J. F. V. Sao Jose do Rio Preto FAMERP, State Med Sch, Hypertens Clin, Sao Paulo, Brazilpt_BR
unicamp.authorPimenta, E. Univ Queensland, Princess Alexandra Hosp, Sch Med, Endocrine Hypertens Res Ctr, Brisbane, Qld, Australiapt_BR
unicamp.authorPimenta, E. Univ Queensland, Princess Alexandra Hosp, Sch Med, Clin Ctr Res Excellence Cardiovasc Dis & Metabol, Brisbane, Qld, Australiapt_BR
unicamp.authorCalhoun, D. A. Univ Alabama, Vasc Biol & Hypertens Program, Birmingham, AL USApt_BR
dc.subjectresistant hypertensionpt_BR
dc.subjectcardiac hypertrophypt_BR
dc.subjectvascular stiffnesspt_BR
dc.subject.wosAngiotensin-aldosterone Systempt_BR
dc.subject.wosBlood-pressure Controlpt_BR
dc.subject.wosArterial Distensibilitypt_BR
dc.description.abstractResistant hypertension (RHTN) includes patients whose blood pressure (BP) is controlled with the use of four or more antihypertensive medications, and is referred to as 'controlled resistant hypertension' (CRH). While specifically comparing patients with CRH and uncontrolled resistant hypertension (UCRH), we hoped to identify distinguishing characteristics that would provide insight into factors contributing to resistance to antihypertensive therapies. RHTN patients were identified as controlled (CRH, n=43) or uncontrolled (UCRH, n=47). No statistical differences were observed between the CRH and UCRH subgroups with respect to age and gender. The body mass index, aldosterone-renin ratio and pulse wave velocity (PWV) were significantly higher in UCRH patients. Although both subgroups showed increased cardiac mass, left ventricular mass index was significantly higher in UCRH compared with CRH patients. Multivariate linear regression analysis indicated that PWV was significantly dependent on age in both UCRH and CRH patients; however, the influence of ageing was more pronounced in the former subgroup. Older age, greater vascular stiffness, higher aldosterone levels and greater left ventricular hypertrophy were significantly associated with lack of BP control in patients with RHTN. These findings suggest important possibilities in terms of preventing and better treating RHTN. Journal of Human Hypertension (2011) 25, 532-538; doi: 10.1038/jhh.2010.95; published online 7 October 2010pt
dc.relation.ispartofJournal Of Human Hypertensionpt_BR
dc.relation.ispartofabbreviationJ. Hum. Hypertens.pt_BR
dc.publisherNature Publishing Grouppt_BR
dc.identifier.citationJournal Of Human Hypertension. Nature Publishing Group, v. 25, n. 9, n. 532, n. 538, 2011.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.provenanceMade available in DSpace on 2014-07-30T16:51:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
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