Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/62755
Type: Artigo de periódico
Title: Characteristics and survival of AIDS patients with hepatitis C: the Brazilian National Cohort of 1995-1996
Author: Marins, JRP
Barros, MBD
Machado, H
Chen, S
Jamal, LF
Hearst, N
Abstract: Background: As AIDS patients live longer, the management of co-morbidities becomes increasingly important. Previous studies from developed countries give conflicting results as to whether co-infection with hepatitis C virus (HCV) lowers the life expectancy of individuals with AIDS. Methods: This retrospective cohort study was based on a medical record review of a nationally representative sample of 2821 adult AIDS cases diagnosed in 1995 and 1996 in Brazil. We compared the characteristics and survival of patients known to be positive and negative for HCV. Results: A total of 833 patients received HCV testing, and the prevalence was 33%. HCV-positive patients received less intensive antiretroviral treatment. The crude mortality was greater for HCV-positive patients (hazard ratio 1.26; P = 0.04), but HCV status was not a significant predictor in a multivariate analysis that included other predictors of survival. Conclusion: Brazilian AIDS patients with hepatitis C have a shorter survival than those without, but this seems to be mainly as a result of their receiving less antiretroviral treatment. We cannot say whether this is because of the fear of hepatotoxicity, an inability to tolerate treatment, or for other reasons. To improve survival, these patients need optimal treatment of their HIV disease. (c) 2005 Lippincott Williams & Wilkins.
Subject: AIDS
Brazil
hepatitis C
HIV
injecting drug use
survival
Country: EUA
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/01.aids.0000191487.69414.88
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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