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|Type:||Artigo de periódico|
|Title:||Changing distribution of human rotavirus serotypes during two epidemic outbreaks of gastroenteritis in Campinas, Sao Paulo, Brazil, 2003-2004: Detection of G6 strains|
|Abstract:||Background: Rotavirus serotypes G1-G4 and G9 are the most important agents of severe diarrhea in children worldwide. Objective: To characterize rotavirus serotypes/genotypes causing two large outbreaks of diarrhea in Campinas, Sao Paulo, during 2003-2004. Study: Rotavirus infection was investigated in 328 stool specimens collected from children and adults with diarrhea by PAGE and RT-PCR and further characterized by semi-nested PCR-typing assays. Results: G3P (26.1%), G9P (18.7%) and GIP (17.9%) were the most frequently detected serotypes/genotypes. G1P was predominant in 2003, but significantly decreased the following year when G3P[81 and G9P prevailed. G5P was identified in about 9% of the typed specimens from each year consistent with its endemic nature in Brazil for over two decades. The other globally common serotypes (G4P and G2P), uncommon G-P combinations, and multiple G serotypes were also found. Rarely found in humans, and not previously reported in Brazil, serotype G6 was identified in three specimens obtained from children in 2004. Conclusion: Multiple rotavirus serotypes were observed co-circulating in the city with serotype predominance changing between the two-year study. This study provides pre-vaccine baseline information on locally endemic strains that might help analysis of post-vaccine data. (C) 2008 Elsevier B.V. All rights reserved.|
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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