Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/62685
Type: Artigo de periódico
Title: Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets
Author: Marcal, AC
Camporez, JPG
Lima-Salgado, TM
Cintra, DE
Akamine, EH
Ribeiro, LM
Almeida, FN
Zanuto, RP
Curi, R
Boldrini, SC
Liberti, EA
Fiamoncini, J
Hirabara, SM
Deschamps, FC
Carpinelli, AR
Carvalho, CRO
Abstract: Long-chain fatty acids are capable of inducing alterations in the homoeostasis of glucose-stimulated insulin secretion (GSIS), but the effect of medium-chain fatty acids (MCFA) is poorly elucidated. In the present study, we fed a normoenergetic MCFA diet to male rats from the age of 1 month to the age of 4 months in order to analyse the effect of MCFA on body growth, insulin sensitivity and GSIS. The 45 % MCFA substitution of whole fatty acids in the normoenergetic diet impaired whole body growth and resulted in increased body adiposity and hyperinsulinaemia, and reduced insulin-mediated glucose uptake in skeletal muscle. In addition, the isolated pancreatic islets from the MCFA-fed rats showed impaired GSIS and reduced protein kinase B alpha (AKT(1)) protein expression and extracellular signal-related kinase isoforms 1 and 2 (ERK1/2) phosphorylation, which were accompanied by increased cellular death. Furthermore, there was a mildly increased cholinergic sensitivity to GSIS. We discuss these findings in further detail, and advocate that they might have a role in the mechanistic pathway leading to the compensatory hyperinsulinaemic status found in this animal model.
Subject: Medium-chain fatty acids
Insulin resistance
Insulin signalling
Pancreatic islets
Country: Inglaterra
Editor: Cambridge Univ Press
Rights: embargo
Identifier DOI: 10.1017/S0007114512004576
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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