Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/62559
Type: Artigo
Title: Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats
Title Alternative: 
Author: Caperuto, L.C.
Anhê, G.F
Amanso, A.M.
Ribeiro, L.M.
Medina, M.C.
Souza, L.C.
Carvalho, O.M.F.
Bordin, S.
Saad, M.J.A.
Carvalho, C.R.O
Abstract: In the present study, we investigated the protein levels and phosphorylation status of the insulin receptor and insulin receptor substrates (IRS-1, IRS-2, and IRS-3) as well as their association with PI(3)-kinase in the rat adipose tissue of two models of insulin resistance: dexamethasone treatment and aging. AKT and atypical PKC phosphorylation detection were also performed. Both models showed decreased insulin-induced IRS-1 and IRS-2 tyrosine phosphorylation, accompanied by reduced protein levels of IRS-1 and IRS-2. Nevertheless, IRS-3 protein level was unchanged in aging but increased in dexamethasone-treated rats. PI(3)-kinase association with IRS-1 was reduced in aged rats, whereas dexamethasone-treated rats showed a reduced IRS-2/ PI(3)-kinase association. However, IRS-3 association with PI(3)-kinase was reduced in both models, as well as insulin-induced AKT and PKC phosphorylation. The alterations described in the present study show that the action of insulin is differently impaired depending on the origin of insulin resistance. These differences might be directly linked to the singular metabolic features of the models we tested
metadata.dc.description.abstractalternative: 
Subject: Tecido adiposo
Dexametasona
Envelhecimento
Resistência à insulina
Country: Alemanha
Editor: Springer
Citation: Endocrine. Humana Press Inc, v. 29, n. 3, n. 391, n. 398, 2006.
Rights: fechado
Identifier DOI: 10.1385/ENDO:29:3:391
Address: https://link.springer.com/article/10.1385/ENDO:29:3:391
Date Issue: 2006
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000240215000002.pdf474.97 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.