Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/62488
Type: Artigo de periódico
Title: Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation
Author: Machado-Neto, JA
Favaro, P
Lazarini, M
Duarte, ADS
Archangelo, LF
Lorand-Metze, I
Costa, FF
Saad, STO
Traina, F
Abstract: Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, report a significantly lower IRS2 expression in MDS cells, compared to normal cells. IRS2 expression was reduced in high-risk, compared to low-risk disease, and positively correlated with neutrophil and platelet counts. IRS2 was upregulated during erythroid differentiation of CD34(+) cells from normal donors and low-risk MDS patients and also during erythroid, granulocytic and megakaryocytic differentiation in cell lines. These results suggest that defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in MDS. (C) 2012 Elsevier Ltd. All rights reserved.
Subject: IRS2
Myelodysplastic syndromes
Erythropoietin
Insulin-like growth factor 1
Differentiation
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2012.03.002
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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