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Type: Artigo de periódico
Title: Diterpenes from Xylopia langsdorffiana Inhibit Cell Growth and Induce Differentiation in Human Leukemia Cells
Author: Branco, MVSC
Anazetti, MC
Silva, MS
Tavares, JF
Diniz, MFFM
Frungillo, L
Haun, M
Melo, PS
Abstract: Two new diterpenes were isolated from stems and leaves of Xylopia langsdorffiana, entatisane-7 alpha,16 alpha-diol (xylodiol) and ent-7 alpha-acetoxytrachyloban-18-oic acid (trachylobane), along with the known 8(17),12E,14-labdatrien-18-oic acid (labdane). We investigated their antitumour effects on HL60, U937 and K562 human leukemia cell lines. We found that xylodiol was the most potent diterpene in inhibiting cell proliferation of HL60, U937 and K562 cells, with mean IC(50) values of 90, 80 and 50 mu M, respectively. Based on the nitroblue tetrazolium (NBT) reduction assay, all the diterpenes were found to induce terminal differentiation in HL60 and K562 cells, with xylodiol being the most effective. NBT reduction was increased by almost 120% after 12 h exposure of HL60 cells to xylodiol at a concentration lower than the IC(50) (50 mu M). Thus, xylodiol inhibited human leukemia cell growth in vitro partly by inducing cell differentiation, and merits further studies to examine its mechanism of action as a potential antitumoural agent.
Subject: Xylopia langsdorffiana
Country: Alemanha
Editor: Verlag Z Naturforsch
Citation: Zeitschrift Fur Naturforschung Section C-a Journal Of Biosciences. Verlag Z Naturforsch, v. 64, n. 41921, n. 650, n. 656, 2009.
Rights: fechado
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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