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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDistribution of Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-alpha in the Peripheral Nervous System of Lewis Rats during Ascending Paresis and Spontaneous Recovery from Experimental Autoimmune Neuritispt_BR
dc.contributor.authorDe La Hoz, CLRpt_BR
dc.contributor.authorCastro, FRpt_BR
dc.contributor.authorSantos, LMBpt_BR
dc.contributor.authorLangone, Fpt_BR
unicamp.author.emailleonilda@unicamp.brpt_BR
unicamp.authorSantos, Leonilda M. B. Langone, Francesco Univ Estadual Campinas, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorDe La Hoz, Cristiane L. R. Univ Estadual Campinas, Dept Anat Cellular Biol & Physiol, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorCastro, Fabiano R. Univ Estadual Campinas, Dept Microbiol & Immunol, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectExperimental autoimmune neuritispt_BR
dc.subjectTumor necrosis factor-alphapt_BR
dc.subjectInducible nitric oxide synthasept_BR
dc.subjectMacrophagept_BR
dc.subjectDemyelinationpt_BR
dc.subjectSpinal rootspt_BR
dc.subjectSciatic nervept_BR
dc.subject.wosExperimental Allergic Neuritispt_BR
dc.subject.wosImmune-mediated Demyelinationpt_BR
dc.subject.wosWallerian Degenerationpt_BR
dc.subject.wosTnf-alphapt_BR
dc.subject.wosMacrophage Recruitmentpt_BR
dc.subject.wosEncephalomyelitispt_BR
dc.subject.wosCellspt_BR
dc.subject.wosModelpt_BR
dc.subject.wosAxonspt_BR
dc.subject.wosNeuropathiespt_BR
dc.description.abstractBackground: Inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha) are pleiotropic molecules with widespread action in autoimmune diseases. Objective: This study characterizes the distribution of iNOS and TNF-alpha in the spinal nerve roots, dorsal root ganglia and sciatic nerve of Lewis rats during experimental autoimmune neuritis (EAN). Methods: Macrophages and neutrophils were identified by immunofluorescence as cellular sources of iNOS and TNF-alpha at various stages of EAN induced by synthetic peptide 26. Results: As the disease progressed, iNOS- and TNF-alpha-bearing cells gradually infiltrated the cauda equina, dorsal root ganglia, Th12-L3 spinal roots, and the sciatic nerve. A severer EAN profile developed when more iNOS- and TNF-alpha-bearing cells were present, and the recovery from EAN was related to the disappearance of these cells and the regeneration of nerve fibers. Conclusions: This is the first report to show iNOS- and TNF-alpha-immunoreactive cells in dorsal root ganglia during EAN, suggesting an underlying pathology for the neuropathic pain behavior in EAN. Our results suggest that the cells bearing iNOS and TNF-alpha in the different parts of the peripheral nervous system are involved in the development of the clinical signs observed at each stage of EAN. Copyright (C) 2009 S. Karger AG, Baselpt
dc.relation.ispartofNeuroimmunomodulationpt_BR
dc.relation.ispartofabbreviationNeuroimmunomodulationpt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherKargerpt_BR
dc.date.issued2010pt_BR
dc.identifier.citationNeuroimmunomodulation. Karger, v. 17, n. 1, n. 56, n. 66, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume17pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage56pt_BR
dc.description.lastpage66pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.karger.com/Services/RightsPermissionspt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1021-7401pt_BR
dc.identifier.wosidWOS:000270560500008pt_BR
dc.identifier.doi10.1159/000243086pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-11-13T18:16:45Z
dc.date.available2015-11-26T16:01:57Z-
dc.date.accessioned2014-11-13T18:16:45Z
dc.date.accessioned2015-11-26T16:01:57Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:01:57Z (GMT). No. of bitstreams: 2 WOS000270560500008.pdf: 437570 bytes, checksum: 86901d04de2c31a912d24c42d727abdb (MD5) WOS000270560500008.pdf.txt: 42467 bytes, checksum: 1fc104aac26225b8baecdd76ad502ca6 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62357pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/62357
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62357-
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