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DC Field | Value | Language |
---|---|---|
dc.contributor.CRUESP | Universidade Estadual de Campinas | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.title | Distribution of Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-alpha in the Peripheral Nervous System of Lewis Rats during Ascending Paresis and Spontaneous Recovery from Experimental Autoimmune Neuritis | pt_BR |
dc.contributor.author | De La Hoz, CLR | pt_BR |
dc.contributor.author | Castro, FR | pt_BR |
dc.contributor.author | Santos, LMB | pt_BR |
dc.contributor.author | Langone, F | pt_BR |
unicamp.author.email | leonilda@unicamp.br | pt_BR |
unicamp.author | Santos, Leonilda M. B. Langone, Francesco Univ Estadual Campinas, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP, Brazil | pt_BR |
unicamp.author | De La Hoz, Cristiane L. R. Univ Estadual Campinas, Dept Anat Cellular Biol & Physiol, BR-13083970 Campinas, SP, Brazil | pt_BR |
unicamp.author | Castro, Fabiano R. Univ Estadual Campinas, Dept Microbiol & Immunol, BR-13083970 Campinas, SP, Brazil | pt_BR |
dc.subject | Experimental autoimmune neuritis | pt_BR |
dc.subject | Tumor necrosis factor-alpha | pt_BR |
dc.subject | Inducible nitric oxide synthase | pt_BR |
dc.subject | Macrophage | pt_BR |
dc.subject | Demyelination | pt_BR |
dc.subject | Spinal roots | pt_BR |
dc.subject | Sciatic nerve | pt_BR |
dc.subject.wos | Experimental Allergic Neuritis | pt_BR |
dc.subject.wos | Immune-mediated Demyelination | pt_BR |
dc.subject.wos | Wallerian Degeneration | pt_BR |
dc.subject.wos | Tnf-alpha | pt_BR |
dc.subject.wos | Macrophage Recruitment | pt_BR |
dc.subject.wos | Encephalomyelitis | pt_BR |
dc.subject.wos | Cells | pt_BR |
dc.subject.wos | Model | pt_BR |
dc.subject.wos | Axons | pt_BR |
dc.subject.wos | Neuropathies | pt_BR |
dc.description.abstract | Background: Inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha) are pleiotropic molecules with widespread action in autoimmune diseases. Objective: This study characterizes the distribution of iNOS and TNF-alpha in the spinal nerve roots, dorsal root ganglia and sciatic nerve of Lewis rats during experimental autoimmune neuritis (EAN). Methods: Macrophages and neutrophils were identified by immunofluorescence as cellular sources of iNOS and TNF-alpha at various stages of EAN induced by synthetic peptide 26. Results: As the disease progressed, iNOS- and TNF-alpha-bearing cells gradually infiltrated the cauda equina, dorsal root ganglia, Th12-L3 spinal roots, and the sciatic nerve. A severer EAN profile developed when more iNOS- and TNF-alpha-bearing cells were present, and the recovery from EAN was related to the disappearance of these cells and the regeneration of nerve fibers. Conclusions: This is the first report to show iNOS- and TNF-alpha-immunoreactive cells in dorsal root ganglia during EAN, suggesting an underlying pathology for the neuropathic pain behavior in EAN. Our results suggest that the cells bearing iNOS and TNF-alpha in the different parts of the peripheral nervous system are involved in the development of the clinical signs observed at each stage of EAN. Copyright (C) 2009 S. Karger AG, Basel | pt |
dc.relation.ispartof | Neuroimmunomodulation | pt_BR |
dc.relation.ispartofabbreviation | Neuroimmunomodulation | pt_BR |
dc.publisher.city | Basel | pt_BR |
dc.publisher.country | Suíça | pt_BR |
dc.publisher | Karger | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.citation | Neuroimmunomodulation. Karger, v. 17, n. 1, n. 56, n. 66, 2010. | pt_BR |
dc.language.iso | en | pt_BR |
dc.description.volume | 17 | pt_BR |
dc.description.issuenumber | 1 | pt_BR |
dc.description.firstpage | 56 | pt_BR |
dc.description.lastpage | 66 | pt_BR |
dc.rights | fechado | pt_BR |
dc.rights.license | http://www.karger.com/Services/RightsPermissions | pt_BR |
dc.source | Web of Science | pt_BR |
dc.identifier.issn | 1021-7401 | pt_BR |
dc.identifier.wosid | WOS:000270560500008 | pt_BR |
dc.identifier.doi | 10.1159/000243086 | pt_BR |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
dc.description.sponsorship1 | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
dc.description.sponsorship1 | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
dc.date.available | 2014-11-13T18:16:45Z | |
dc.date.available | 2015-11-26T16:01:57Z | - |
dc.date.accessioned | 2014-11-13T18:16:45Z | |
dc.date.accessioned | 2015-11-26T16:01:57Z | - |
dc.description.provenance | Made available in DSpace on 2014-11-13T18:16:45Z (GMT). No. of bitstreams: 1 WOS000270560500008.pdf: 437570 bytes, checksum: 86901d04de2c31a912d24c42d727abdb (MD5) Previous issue date: 2010 | en |
dc.description.provenance | Made available in DSpace on 2015-11-26T16:01:57Z (GMT). No. of bitstreams: 2 WOS000270560500008.pdf: 437570 bytes, checksum: 86901d04de2c31a912d24c42d727abdb (MD5) WOS000270560500008.pdf.txt: 42467 bytes, checksum: 1fc104aac26225b8baecdd76ad502ca6 (MD5) Previous issue date: 2010 | en |
dc.identifier.uri | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62357 | pt_BR |
dc.identifier.uri | http://www.repositorio.unicamp.br/handle/REPOSIP/62357 | |
dc.identifier.uri | http://repositorio.unicamp.br/jspui/handle/REPOSIP/62357 | - |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
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WOS000270560500008.pdf | 427.31 kB | Adobe PDF | View/Open |
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