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|Type:||Artigo de periódico|
|Title:||Novel Supramolecular Palladium Catalyst for the Asymmetric Reduction of Imines in Aqueous Media|
|Author:||da Silva, WA|
|Abstract:||A novel approach to the asymmetric reduction of dihydro-p-carboline derivatives to the corresponding tetrahydro-beta-carbolines is described based on the supramolecular lyophilized complex formed from beta-cyclodextrin/imines as an enzyme mimetic and palladium hydride as the reducing agent. The methodology allowed us to develop a short and efficient preparation of (R)-harmicine and (R)-deplancheine alkaloids in high overall yields and ee of 89 and 90%, respectively.|
|Editor:||Amer Chemical Soc|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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