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Type: Artigo de periódico
Title: Novel Supramolecular Palladium Catalyst for the Asymmetric Reduction of Imines in Aqueous Media
Author: da Silva, WA
Rodrigues, MT
Shankaraiah, N
Ferreira, RB
Andrade, CKZ
Pilli, RA
Santos, LS
Abstract: A novel approach to the asymmetric reduction of dihydro-p-carboline derivatives to the corresponding tetrahydro-beta-carbolines is described based on the supramolecular lyophilized complex formed from beta-cyclodextrin/imines as an enzyme mimetic and palladium hydride as the reducing agent. The methodology allowed us to develop a short and efficient preparation of (R)-harmicine and (R)-deplancheine alkaloids in high overall yields and ee of 89 and 90%, respectively.
Country: EUA
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/ol9011772
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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