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Type: Artigo de periódico
Title: Novel R-(+)-limonene-based thiosemicarbazones and their antitumor activity against human tumor cell lines
Author: Vandresen, F
Falzirolli, H
Batista, SAA
da Silva-Giardini, APB
de Oliveira, DN
Catharino, RR
Ruiz, ALTG
de Carvalho, JE
Foglio, MA
da Silva, CC
Abstract: In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. Almost all of tested thiosemicarbazones were especially sensitive to prostate cells (PC-3). Derivatives 5, 6, 8, 9, 10, 11 and 13 presented the most potent antitumor activity against PC-3 cells. These compounds showed lower value of GI(50) (0.04-0.05 mu M) than the reference drug paclitaxel, besides a high selectivity for the same cell line. The 4-fluorobenzaldehyde derivative 10 was the most selective compound for prostate cells, while 2-hydroxybenzaldehyde derivative 8 was the most active compound, with potent antitumor activity against all tested cell lines. (C) 2014 Elsevier Masson SAS. All rights reserved.
Subject: R-(+)-limonene
Prostate cancer cells
Country: França
Editor: Elsevier France-editions Scientifiques Medicales Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2014.03.086
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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