Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/62080
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampHyslop, Stephenpt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.contributor.authorunicampCosta, Soraia Katia Pereirapt_BR
dc.contributor.authorunicampMoreno Junior, Heitorpt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampMetze, Konradinpt_BR
dc.typeArtigopt_BR
dc.titleNon-specific inhibitors of nitric oxide synthase cause myocardial necrosis in the ratpt_BR
dc.contributor.authorNathan, L.P.pt_BR
dc.contributor.authorHyslop, S.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.contributor.authorCosta, S.K.P.pt_BR
dc.contributor.authorMoreno, H.pt_BR
dc.contributor.authorZatz, R.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorMetze, K.pt_BR
unicamp.authorUNICAMP,FAC MED SCI,DEPT PHARMACOL,CAMPINAS,SP,BRAZIL UNICAMP,FAC MED SCI,DEPT PATHOL,CAMPINAS,SP,BRAZIL UNIV SAO PAULO,SCH MED,DEPT NEPHROL,SAO PAULO,BRAZILpt_BR
dc.subjectInfarto do miocárdiopt_BR
dc.subjectPressão sanguíneapt_BR
dc.subjectInibidores enzimáticospt_BR
dc.subject.otherlanguageMyocardial infarctionpt_BR
dc.subject.otherlanguageBlood pressurept_BR
dc.subject.otherlanguageEnzyme inhibitorspt_BR
dc.subject.wosAnginapt_BR
dc.subject.wosModelpt_BR
dc.description.abstractTo study the effect of acute nitric oxide (NO) inhibition on the rat heart both in vitro and in vivo, male Wistar rats received a single bolus injection of saline, N-omega-nitro-L-arginine methyl ester (L-NAME; 0.5, 1.5, 5.0, 15.0 and 45.0 mg/kg) and D-NAME (45.0 mg/kg). 2. Animals were killed 72 h after the bolus injection of L-NAME and the hearts were removed and studied under light microscopy. In other groups of animals, saline, L-NAME and D-NAME were administered as above and the mean arterial blood pressure (MABP/carotid) was recorded, Furthermore, L-NAME was also administered in the drinking water (20 mg/kg per day) for 72 h and animals were then killed and their hearts evaluated as described above, Hearts of control animals were perfused in vitro and coronary flow was measured following saline, L-NAME (45 mu g/heart) and D-NAME (45 mu g/heart). 3. Areas of necrosis were observed in the left ventricle of animals that had received L-NAME at 5.0, 15.0 and 45.0 mg/kg, Also, only doses higher than 1.5 mg/kg caused an important increase in MABP. The frequency and extent of the lesions paralleled the dose of L-NAME administered and no lesions were observed in D-NAME- and saline-treated animals. 4. The oral administration of L-NAME also caused myocardial lesions similar to those described above, but the frequency and extent of these lesions were more discrete compared with those observed following 5.0 mg/kg, i.v., L-NAME. 5. Bolus injection of L-NAME into control rat hearts in vitro resulted in a small and transient fall in coronary flow (17.2 +/- 1.4 and 12.2 +/- 1.2 mL/min before and after L-NAME administration, respectively) within 30 s and this was followed 4.5 min later by a further (11.5 +/- 1.6 mL/min) decrease. The administration of D-NAME to control hearts caused no change in coronary flow. 6. In conclusion, the acute inhibition of NO biosynthesis by L-NAME causes myocardial necrosis, Both high levels of MABP and a small but significant reduction in coronary flow (associated or not) can be responsible for the lesions we foundpt
dc.relation.ispartofClinical and experimental pharmacology and physiologypt_BR
dc.relation.ispartofabbreviationClin. exp. pharmacol. physiol.pt_BR
dc.publisher.cityCarltonpt_BR
dc.publisher.countryAustraliapt_BR
dc.publisherBlackwell Sciencept_BR
dc.date.issued1997pt_BR
dc.date.monthofcirculationMaypt_BR
dc.identifier.citationClinical And Experimental Pharmacology And Physiology. Blackwell Science, v. 24, n. 5, n. 349, n. 352, 1997.pt_BR
dc.language.isoengpt_BR
dc.description.volume24pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage349pt_BR
dc.description.lastpage352pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.sourceWOSpt_br
unicamp.cruespUSPpt_BR
dc.identifier.issn0305-1870pt_BR
dc.identifier.wosidWOS:A1997WX25800010pt_BR
dc.identifier.doi10.1111/j.1440-1681.1997.tb01200.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1681.1997.tb01200.xpt_BR
dc.description.sponsorshipFAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1FAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.date.available2014-12-16T11:36:25Z
dc.date.available2015-11-26T16:22:38Z-
dc.date.accessioned2014-12-16T11:36:25Z
dc.date.accessioned2015-11-26T16:22:38Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:36:25Z (GMT). No. of bitstreams: 1 WOSA1997WX25800010.pdf: 420932 bytes, checksum: a755f173b990ddd597bc0d124b62062f (MD5) Previous issue date: 1997en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:22:38Z (GMT). No. of bitstreams: 2 WOSA1997WX25800010.pdf: 420932 bytes, checksum: a755f173b990ddd597bc0d124b62062f (MD5) WOSA1997WX25800010.pdf.txt: 19279 bytes, checksum: 3ac4e6bcb9e5ca94d509ef694b5b73f2 (MD5) Previous issue date: 1997en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62080pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/62080
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62080-
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.sourceA1997WX25800010-
dc.creator.orcid0000-0002-9293-3638pt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.creator.orcid0000-0001-6330-697Xpt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcid0000-0003-0742-8846pt_BR
dc.type.formArtigo original-
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