Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61977
Type: Artigo de periódico
Title: Non-effect of p22-phox-930A/G polymorphism on end-organ damage in Brazilian hypertensive patients
Author: Sales, ML
Ferreira, MCS
Leme, CA
Velloso, LA
Gallani, MCJ
Colombo, RCR
Franchini, KG
Nadruz, W
Abstract: The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. 1,2 The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD( P) H oxidase-mediated oxidative stress and hypertension. 3,4 We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.(2) Thus, the aim of the present report was to investigate the role of p22-phox -930A/G polymorphism on end-organ damage in hypertensive patients.
Country: Inglaterra
Editor: Nature Publishing Group
Rights: fechado
Identifier DOI: 10.1038/sj.jhh.1002170
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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