Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61916
Type: Artigo de periódico
Title: NFAT Isoforms Regulate Muscle Fiber Type Transition without Altering CaN during Aerobic Training
Author: Vechetti, I
Aguiar, AF
de Souza, RWA
Almeida, FLA
Dias, HBD
Silva, MAD
Carani, FR
Ferraresso, RLP
Carvalho, RF
Dal-Pai-Silva, M
Abstract: The purpose of this study was to determine whether the aerobic training-induced fiber-type transition in different muscles is associated with alterations in NFAT isoforms gene expression. We hypothesized that the aerobic training-induced fiber-type transition would be mediated by NFATc1-c3 isoforms without altering the CaN expression. Male Wistar rats (80 days old) were divided into a trained group (T; n=8) that underwent an 8-wk swimming endurance training program (5 days/week) and a control group (C; n=8). After the experimental period, the animals were sacrificed, and the soleus (SOL) and plantaris (PL) muscles were collected for morphometrical, histochemical and molecular analyses. Aerobic training induced a type I-to-type IIA fiber transition in the SOL muscle and a type IIB-to-type IIA fiber transition in the PL muscle, which were concomitant with a significant (p<0.05) increase in NFATc1-c3 gene expression in both the SOL and PL muscles. In contrast, the expression levels of calcineurin (CaN) and NFATc4 remained unchanged. Therefore, our results showed that fiber type switching induced by aerobic training is mediated by NFATc1-c3 isoforms without altering the CaN expression.
Subject: endurance training
calcineurin
NFAT isoforms
fiber-type
skeletal muscle
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Rights: aberto
Identifier DOI: 10.1055/s-0032-1331758
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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