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|Type:||Artigo de periódico|
|Title:||Differential cytokine expressions affect the severity of peri-implant disease|
de Mendonca, AC
|Abstract:||Objective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory-[interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] and osteoclastogenesis-related factors [receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-alpha mRNA levels were higher in SP, followed by IP and MC (P < 0.05). IL-4 was higher in HI, followed by MC, SP and IP (P < 0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups (P=0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased (P < 0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP (P < 0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases.|
|Editor:||Wiley-blackwell Publishing, Inc|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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