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|Type:||Artigo de periódico|
|Title:||DIFFERENCES IN K+ PERMEABILITY BETWEEN CULTURED ADULT AND NEONATAL RAT ISLETS OF LANGERHANS IN RESPONSE TO GLUCOSE, TOLBUTAMIDE, DIAZOXIDE, AND THEOPHYLLINE|
|Abstract:||The effects of glucose, tolbutamide, and diazoxide on K+ permeability in neonatal and adult rat pancreatic islets, maintained in culture 1 week, were investigated by measuring the Rb-86 outflow rate from prelabeled islets. In the absence of glucose, the Rb-86 efflux was significantly lower in neonatal than adult islets. Raising the glucose concentration to 2.8, 5.6, 8.3, and 11.1 mM produced a marked reduction in the Rb-86 efflux in adult islets but only a minor reduction in neonatal islets. The effect of tolbutamide to reduce, and diazoxide to increase, the Rb-86 efflux was also less in neonatal islets. These results are discussed with respect to previously reported differences in insulin secretion from neonatal and adult islets in culture.|
|Subject:||ADULT AND NEONATAL CULTURED RAT ISLETS|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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