Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61760
Type: Artigo de periódico
Title: DIFFERENCES IN K+ PERMEABILITY BETWEEN CULTURED ADULT AND NEONATAL RAT ISLETS OF LANGERHANS IN RESPONSE TO GLUCOSE, TOLBUTAMIDE, DIAZOXIDE, AND THEOPHYLLINE
Author: BOSCHERO, AC
TOMBACCINI, D
CARNEIRO, EM
ATWATER, IJ
Abstract: The effects of glucose, tolbutamide, and diazoxide on K+ permeability in neonatal and adult rat pancreatic islets, maintained in culture 1 week, were investigated by measuring the Rb-86 outflow rate from prelabeled islets. In the absence of glucose, the Rb-86 efflux was significantly lower in neonatal than adult islets. Raising the glucose concentration to 2.8, 5.6, 8.3, and 11.1 mM produced a marked reduction in the Rb-86 efflux in adult islets but only a minor reduction in neonatal islets. The effect of tolbutamide to reduce, and diazoxide to increase, the Rb-86 efflux was also less in neonatal islets. These results are discussed with respect to previously reported differences in insulin secretion from neonatal and adult islets in culture.
Subject: ADULT AND NEONATAL CULTURED RAT ISLETS
GLUCOSE
K+ PERMEABILITY
RB-86 EFFLUX
SULFONYLUREAS
THEOPHYLLINE
Editor: Lippincott-raven Publ
Rights: fechado
Identifier DOI: 10.1097/00006676-199301000-00010
Date Issue: 1993
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.