Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61702
Type: Artigo de periódico
Title: DIAZEPAM IN RATS SALIVARY-GLANDS
Author: SILVA, FA
CURY, JA
SILVA, WAB
Abstract: The flow of saliva plays a role in the pathogenesis of dental caries. Xerostomia induced by drugs can increase dental caries. In this research was studied the effect of a sedative hypnotic drug (diazepan in rats salivary glands). It was used 115 rats with 21 days years old. The rats received daily injection of diazepan (0,28 mg/kg), or NaCl 0,9%, during 30 days. The salivary flow rate and saliva protein concentration were analysed. The glycogen concentration, G6PD activity and the metabolic quocient were determined in the submandibular glands. The showed that the only significative difference was a decrease in the flow of saliva when the rats received diazepan. It was suggested that their chronic administration of diazepan doesn't change the rat salivary gland metabolism but inhibit its secretion rate.
Country: Brasil
Editor: Moreira Jr Editora Ltda
Rights: aberto
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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