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|Type:||Artigo de periódico|
|Title:||Diastereoselective formation of a quaternary center in a pyroglutamate derivative. Formal synthesis of Monatin|
|Abstract:||In this communication we describe a highly diastereoselective formation of a quaternary center present in the structure of Monatin, a potent sweetening agent isolated from natural sources. The synthesis of a derivative useful for biological studies on the interactions of this type of sweetening substance on taste receptors is described. The strategy relies on the oxidation of an gy enolate originating from a pyroglutamate derivative followed by a highly diastereoselective alkylation with an electrophile obtained from indole. (C) 2001 Elsevier Science Ltd. All rights reserved.|
|Editor:||Pergamon-elsevier Science Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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