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|Type:||Artigo de periódico|
|Title:||Diagnosis of Scott syndrome in patient with bleeding disorder of unknown cause|
De Paula, EV
|Abstract:||Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising the platelet procoagulant activity, thrombin generation and, thus, the clot formation. We report a case of a 17-year-old female adolescent with bleeding episodes of unknown cause. She had normal coagulation, but altered platelet aggregation under arteriolar flow, indicating platelet dysfunction. Furthermore, the expression of Annexin V was markedly reduced and the diagnosis of Scott syndrome was established. She was treated with platelet transfusions and demonstrated a clinical improvement. Scott syndrome may be investigated in cases with bleeding history and normal coagulation tests. Blood Coagul Fibrinolysis 23:75-77 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.|
|Editor:||Lippincott Williams & Wilkins|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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