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Type: Artigo de periódico
Title: Diagnosis of Scott syndrome in patient with bleeding disorder of unknown cause
Author: Flores-Nascimento, MC
Orsi, FLA
Yokoyama, AP
Pereira, FG
Lorand-Metze, I
De Paula, EV
Castro, V
Annichino-Bizzacchi, JM
Abstract: Scott syndrome is a rare bleeding disorder due to an impaired exposure of phosphatidilserine on the platelet membrane, compromising the platelet procoagulant activity, thrombin generation and, thus, the clot formation. We report a case of a 17-year-old female adolescent with bleeding episodes of unknown cause. She had normal coagulation, but altered platelet aggregation under arteriolar flow, indicating platelet dysfunction. Furthermore, the expression of Annexin V was markedly reduced and the diagnosis of Scott syndrome was established. She was treated with platelet transfusions and demonstrated a clinical improvement. Scott syndrome may be investigated in cases with bleeding history and normal coagulation tests. Blood Coagul Fibrinolysis 23:75-77 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Subject: Annexin V
bleeding disorder
Scott syndrome
Country: EUA
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/MBC.0b013e32834d0c81
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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