Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61637
Type: Artigo de periódico
Title: Development, Characterization, and Cellular Adhesion of Poly(L-Lactic Acid)/Poly(Caprolactone Triol) Membranes for Potential Application in Bone Tissue Regeneration
Author: Mistura, DV
Messias, AD
Duek, EAR
Duarte, MAT
Abstract: Poly(L-lactide)/poly(caprolactone triol) (PLLA/PCL-T) membranes were prepared by solution casting in 100/0, 90/10, and 70/30 (w/w) ratios. The membranes were analyzed by dynamic mechanical analysis, differential scanning calorimetry, and mechanical tests. The thermal analysis showed that the 90/10 and 70/30 preparations were partly miscible systems. The glass transition temperature (T-g) of PLLA decreases as the PCL-T concentration increases, which implies that PCL-T has a plasticizer function. An in vitro study with osteoblastic cells isolated from the calvariae of rats was performed in all preparations. The results obtained in this study showed that the addition of PCL-T to the PLLA matrix modifies its mechanical, thermal, and biological properties. These blends could be useful for tissue engineering for bone applications.
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1111/aor.12232
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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