Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61559
Type: Artigo de periódico
Title: Development of a polymer-coated stationary phase with improved chemical stability in alkaline mobile phases
Author: Faria, AM
Silva, CR
Collins, CH
Jardim, ICSF
Abstract: An endcapped stationary phase is prepared by thermal immobilization of poly(methyltetradecylsiloxane) (PMTDS) onto a doubly zirconized silica support followed by endcapping using a mixture of hexamethyldisilazane and trimethylchlorosilane. The preparation of the Si-Zr(PMTDS)ec phase shows good repeatability with RSD < 3.0% for carbon loadings and column efficiency. This new stationary phase has a lower density of residual hydroxyl groups, according to spectroscopic methods while basic compounds from the Tanaka and Engelhardt test mixtures are eluted with essentially symmetric peaks. Furthermore, the stability of the Si-Zr(PMTDS)ec stationary phase, measured using an accelerated aging test, is twice as great as the stability of a similar nonendcapped phase. The new phase shows promise for the separation of basic pharmaceuticals.
Subject: endcapping
PMTDS
stability
stationary phases
zirconized silica
Country: Alemanha
Editor: Wiley-v C H Verlag Gmbh
Rights: fechado
Identifier DOI: 10.1002/jssc.200700607
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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