Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61497
Type: Artigo de periódico
Title: Determining the C-Reactive Protein Level in Patients With Different Clinical Forms of Chagas Disease
Author: da Silva, CA
Fattori, A
Sousa, AL
Mazon, SB
Alegre, SM
Almeida, EA
Guariento, ME
Abstract: Chagas disease is caused by Trypanosoma cruzi and remains a health problem in the developing countries of South America. The condition leads to cardiac conduction disturbances and chronic heart failure. In this study, 136 individuals were evaluated by the Chagas Disease Study Group of the Hospital de la Universidad Estatal de Campinas in Brazil to determine the relationship between chronic heart failure and the serum C-reactive protein (CRP) level. When patients were stratified according to the different clinical presentations of Chagas disease, it was found that the CRP levels in those with severe heart disease and non-Chagasic cardiopathy were significantly higher than in controls or those with mild heart disease (P<.05), even when participants were stratified by age (i.e. <40 and <40 years). There was a direct linear correlation between age and CRP level, such that the older the individual, the higher the CRP level. These data provide further evidence for an association between chronic inflammation and the development of heart failure. Although CRP elevations are not exclusively related to Chagas disease, the CRP level may be a useful marker for the progression of Chagas disease to a more advanced phase.
Subject: Chagas disease
Inflammation
C-reactive protein
Heart failure
Country: Espanha
Editor: Ediciones Doyma S A
Rights: fechado
Identifier DOI: 10.1016/S0300-8932(10)70233-5
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000281193000013.pdf108.64 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.