Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/61436
Type: Artigo de periódico
Title: Determination of the allele frequencies of three polymorphisms in the promoter region of the human protein C gene in three Brazilian ethnic groups
Author: Mendes, CPO
Hackel, C
Arruda, VR
Annichino-Bizzacchi, JM
Abstract: The frequencies of three polymorphisms in the promoter region of the human protein C gene have been determined in th ree ethnic groups of the Brazilian population, The allele frequencies observed in south-eastern Brazilian Caucasians and Blacks were similar to the values obtained for the Dutch population and were different from those observed in Amazonian Indians living in the north of the country, The most frequent genotypic combination found in this latter group was the CC/GG/<(AA)under bar> genotype, which is very rare among Caucasians, The complete heterozygous genotype CT/AG/<(AT)under bar> was the most frequent both in Brazilian Caucasians and Blacks, Among 27 possible genotypic combinations, 21 were found in the Caucasian group and 15 in Blacks, revealing a high degree of genetic diversity in south-eastern Brazilian populations.
Subject: protein C
promoter
polymorphisms
Country: Suíça
Editor: Karger
Rights: fechado
Identifier DOI: 10.1159/000022836
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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