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|Type:||Artigo de periódico|
|Title:||DETERMINATION OF DL50 OF THE SIALOTOXIN-III AND YOUR RELATIONSHIP WITH THE TESTOSTERONE IN MICE|
|Abstract:||The purpose of this work was to determinate the DL50 of the Sialotoxin III, isolated by PINHEIRO (14), in female and male mice, as well in castrated male mice and female treated by testosterone. Effectively, the Sialotoxin III is a toxic ratio produced by salivary glands of male mice that promotes a lot of biological reactions and death when it is administrated in mice. The DL50 of this toxine on mice was aproximately 133,91 ug/kg, while on females, which are much more sensible, it was 38,36 ug/kg. On the other hand, the orchiectomized animals and females treated by testosterone presented a DL50 of 56,42 ug/kg and 77,72 ug respectively, showing therefore a protector testosterone action in relation to the toxicity of this substance confirming the evidence that the Sialotoxins are dependent androgens.|
|Editor:||Inst Tecnologia Parana|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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